Shut Up Flower Boy Band is centered around a high school band known as "Eye Purification." The drama depicts their friendships, loves and passion for music.   Byung-Hee (Lee Min-Ki), Kwon Ji-Hyuk (Sung Joon), Lee Hyun-Soo (L (Kim Myung-Soo)), Jang Do-Il (Lee Hyun-Jae), Kim Ha-Jin (Yoo Min-Kyu) and Seo Kyung-Jong (Kim Min-Suk) are the members in "Eye Purification." They all attend Dong-Nae High School, a school set to close down due to redevelopment. The band members don't have much interest in studying. Byung-Hee keeps proposing that they all drop out of school, but the others take his comment as a joke. Byung-Hee is interested in finding a muse that will inspire him to write great music.  One evening, "Eye Purification" perform at a bar, but due to the loud volume from their show the police enter the bar. The band are able to escape. The next morning, Byung-Hee wakes up on a bed next to a girl. The girl's father knocks on the door, shouting "Open the door!" The girl tries to hold the door closed until Byung-Hee can leave the room, but her father breaks in. Byung-Hee is shocked to see her father. The girl's father is Byung-Hee's teacher! Byung-Hee escapes.  The band members meet and go to to school. A meeting takes place between students and faculty, to learn which schools they will transfer too. The band members of "Eye Purification" must transfer to Jung-Sang High School. Their new school features a sterling reputation, good facilities and kids from rich families unlike Dong-Nae High School.  Meanwhile, the band members go to Nakwon Shopping Center to buy a drum. At the shopping center, Byung-Hee see a girl Im Soo-Ah (Jo Bo-Ah). Byung-Hee feels a connection with her and believes she might be the muse he is looking for. While Byung-Hee starts a conversation with her, Kwon Ji-Hyuk walks up to them. Kwon Ji-Hyuk notices her name tag and her high school uniform. Kwon Ji-Hyuk drags Byung-Hee away. When Byung-Hee returns, the girl is no longer there. The band members sit on a bench in front of a crosswalk hoping to see the girl again. They spot the girl walking across the crosswalk. Right before she is about to fall down in front Kwon Ji-Hyuk, he is able to hold her up. The girl walks off and gets into a car.  The girl, Im Soo-Ah, is a student at Jung-Sang High School. She is a long time friend of Yoo Seung-Hoon (Jung Eui-Chul), fellow classmate and leader of the band "Strawberry Fields." Yoo Seung-Hoon has feelings for Im Soo-Ah. Yoo-Seung-Hoo is from a rich family, while Im Soo-Ah came from a rich family, but her father became bankrupt. Im Soo-Ah went to Nakwon Shopping Center to buy a present for Yoo Seung-Hoon. After she got into the car that her father is driving, he hands her a note with an adress where she is to live. Her father tells her that she won't have to stay there long and he will come for her. That night, she goes to the address. Her new apartment is a rooftop efficiency, directly adjacent to the rooftop efficiency where Kwon Ji-Hyuk lives.  At night, the band members goes out to perform on the street. At the same time, "Strawberry Fields" comes to perform nearby. Im Soo-Ah is there to watch Yoo Seung-Hoon perform. Byung-Hee sees her and gives her a hug. Yoo Seung-Hoon sees the hug and a fight quickly ensues between Byung-Hee from "Eye Purification" and Yoo Seung-Hoon from "Strawberry Fields." Bodyguards for Yoo Seung-Hoon quickly steps in and beats up the members of "Eye Purification."  The next day, the guys from "Eye Purification" go to their new school ... Jung-Sang High School.