Syndrome is a medical drama set in the neurosurgery world.  Lee Hae-Jo (Han Hye-Jin) is a first year resident specializing in neurosurgery. She didn't graduated from a premiere medical school, but she is determined to become the best neurosurgeon.  Cha Yeo-Wook (Song Chang-Eui) is also a first year neurosurgery resident. Unlike Hae-Jo, Cha Yeo-Wook graduated from the best medical school and is the grandson of the chairman of the board at the Korea University Hospital. His background to become a doctor is impecable.  Kang Eun-Hyun (Park Gun-Hyung) is the chief resident of neurosurgery.  A love triangle begins between these three people.